Article
T cell epitope content comparison (EpiCC) analysis demonstrates a bivalent PCV2 vaccine has greater T cell epitope overlap with field strains than monovalent PCV2 vaccines.
Veterinary immunology and immunopathology - 1 May 2020
Bandrick Meggan, Gutiérrez Andres H, Desai Prerak, Rincon Gonzalo, Martin William D, Terry Frances E, De Groot Anne S, Foss Dennis L
Abstract excerpt
Porcine circovirus type 2 (PCV2) has one of the highest evolutionary rates among DNA viruses. Traditionally, PCV2 vaccines have been based on the 2a genotype as this was the first genotype discovered. Today, eight genotypes of PCV2 viruses have been identified, and, taken together with the rapid evolutionary rate, propensity to recombine, and high rate of vaccination, further variation in PCV2 is expected. For...
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