Article
A novel diagnostic system to evaluate epidermal growth factor receptor impact as a prognostic and therapeutic indicator for lung adenocarcinoma.
Scientific reports - 10 Apr 2020
Takakuwa Kazuya, Mogushi Kaoru, Han Min, Fujii Tomoaki, Hosoya Masaki, Yamanami Arina, Akita Tomomi, Yamashita Chikamasa, Hayashida Tetsu, Kato Shunsuke, Yamaguchi Shigeo
Abstract excerpt
Many driver pathways for cancer cell proliferation have been reported. Driver pathway activation is often evaluated based on a single hotspot mutation such as EGFR L858R. However, because of complex intratumoral networks, the impact of a driver pathway cannot be predicted based on only a single gene mutation. Here, we developed a novel diagnostic system named the "EGFR impact score" which is based on multiplex...
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