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Article

Functional Genomics of the Pediatric Obese Asthma Phenotype Reveal Enrichment of Rho-GTPase Pathways.

American journal of respiratory and critical care medicine - 15 Jul 2020

Rastogi Deepa, Johnston Andrew D, Nico John, Loh Lip Nam, Jorge Yurydia, Suzuki Masako, Macian Fernando, Greally John M

Abstract excerpt

Rationale: Obesity-related asthma disproportionately affects minority children and is associated with nonatopic T-helper type 1 (Th1) cell polarized inflammation that correlates with pulmonary function deficits. Its underlying mechanisms are poorly understood.Objectives: To use functional genomics to identify cellular mechanisms associated with nonatopic inflammation in obese minority children with...

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Identifiers

PMID: 32255672
DOI: 10.1164/rccm.201906-1199OC
PMCID: PMC7365356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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