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Article

A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma.

American journal of respiratory and critical care medicine - 1 Jul 2020

Gomez Jose L, Chen Ailu, Diaz Maria Paula, Zirn Nicholas, Gupta Amolika, Britto Clemente, Sauler Maor, Yan Xiting, Stewart Emma, Santerian Kyle, Grant Nicole, Liu Qing, Fry Rebecca, Rager Julia, Cohn Lauren, Alexis Neil, Chupp Geoffrey L

Abstract excerpt

Rationale: MicroRNAs are potent regulators of biologic systems that are critical to tissue homeostasis. Individual microRNAs have been identified in airway samples. However, a systems analysis of the microRNA-mRNA networks present in the sputum that contribute to airway inflammation in asthma has not been published.Objectives: Identify microRNA and mRNA networks in the sputum of patients with asthma.Methods: We...

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Identifiers

PMID: 32255668
DOI: 10.1164/rccm.201912-2360OC
PMCID: PMC7328332

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