Article
MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage.
Circulation. Cardiovascular genetics - 1 Oct 2017
Willinger Christine M, Rong Jian, Tanriverdi Kahraman, Courchesne Paul L, Huan Tianxiao, Wasserman Gregory A, Lin Honghuang, Dupuis Josée, Joehanes Roby, Jones Matthew R, Chen George, Benjamin Emelia J, O'Connor George T, Mizgerd Joseph P, Freedman Jane E, Larson Martin G, Levy Daniel
Abstract excerpt
BACKGROUND: Cigarette smoking increases risk for multiple diseases. MicroRNAs regulate gene expression and may play a role in smoking-induced target organ damage. We sought to describe a microRNA signature of cigarette smoking and relate it to smoking-associated clinical phenotypes, gene expression, and lung inflammatory signaling. METHODS AND RESULTS: Expression profiling of 283 microRNAs was conducted on whole...
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