Article
BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition.
Cold Spring Harbor molecular case studies - 1 Apr 2020
Obasaju Patience, Shahab Shubin, Dunn Emily, Rhee Daniel S, Jiang LiQun, Dome Jeffrey S, Friedman Alan D, Argani Pedram, Pratilas Christine A
Abstract excerpt
Wilms tumor (WT) is the most common renal malignancy of childhood and accounts for 6% of all childhood malignancies. With current therapies, the 5-yr overall survival (OS) for children with unilateral favorable histology WT is greater than 85%. The prognosis is worse, however, for the roughly 15% of patients who relapse, with only 50%-80% OS reported in those with recurrence. Herein, we describe the extended and...
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