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Article

Exploring Neuronal Vulnerability to Head Trauma Using a Whole Exome Approach.

Journal of neurotrauma - 1 Sept 2020

Ibrahim Omar, Sutherland Heidi G, Maksemous Neven, Smith Robert, Haupt Larisa M, Griffiths Lyn R

Abstract excerpt

Brain injuries are associated with oxidative stress and a need to restore neuronal homeostasis. Mutations in ion channel genes, in particular CACNA1A, have been implicated in familial hemiplegic migraine (FHM) and in the development of concussion-related symptoms in response to trivial head trauma. The aim of this study was to explore the potential role of variants in other ion channel genes in the development of...

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Identifiers

PMID: 32233732
DOI: 10.1089/neu.2019.6962
PMCID: PMC7462038

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