Investigating genetic susceptibility to concussion through rare variants in ion channel and neurotransmission genes.

doi:10.1007/s00415-026-14139-8

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Article

Investigating genetic susceptibility to concussion through rare variants in ion channel and neurotransmission genes.

Journal of neurology - 12 Sept 2026

Maher Bridget H, Maksemous Neven, Sutherland Heidi G, Smith Robert A, Dabash Omar, Greenhow Annette, Nasralla Fatima A, Nyholt Dale R, van den Maagdenberg Arn M J M, Lea Rodney A, Griffiths Lyn R

Abstract excerpt

Some individuals appear more susceptible to concussion or mild traumatic brain injury (mTBI) and the severity, range, and the persistence of post-concussion symptoms vary considerably between affected individuals. Genetic factors are likely to contribute to this variability. Symptomatic overlap of post-concussion syndrome with neurological conditions such as familial hemiplegic migraine (FHM) caused by rare...

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Topics

Humans
Genetic Predisposition to Disease
Female
Synaptic Transmission
Brain Concussion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Ion Channels

Adult

Exome Sequencing

Young Adult

Middle Aged

Adolescent

Source

Open in PubMed Open full text

Identifiers

PMID: 42730919
DOI: 10.1007/s00415-026-14139-8
PMCID: PMC13570918

Genes

SCN9A
SNCAIP

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