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Article

Non-additive (dominance) effects of genetic variants associated with refractive error and myopia.

Molecular genetics and genomics : MGG - 1 Jul 2020

Pozarickij Alfred, Williams Cathy, Guggenheim Jeremy A

Abstract excerpt

Genome-wide association studies (GWAS) have revealed that the genetic contribution to certain complex diseases is well-described by Fisher's infinitesimal model in which a vast number of polymorphisms each confer a small effect. Under Fisher's model, variants have additive effects both across loci and within loci. However, the latter assumption is at odds with the common observation of dominant or recessive rare...

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Identifiers

PMID: 32227305
DOI: 10.1007/s00438-020-01666-w
PMCID: PMC7297706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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