Article
Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence.
eLife - 30 Mar 2020
Alessio Nicola, Squillaro Tiziana, Di Bernardo Giovanni, Galano Giovanni, De Rosa Roberto, Melone Mariarosa A B, Peluso Gianfranco, Galderisi Umberto
Abstract excerpt
Senescent cells secrete several molecules, collectively named senescence-associated secretory phenotype (SASP). In the SASP of cells that became senescent following several in vitro chemical and physical stress, we identified the IGFBP-4 protein that can be considered a general stress mediator. This factor appeared to play a key role in senescence-paracrine signaling. We provided evidences showing that genotoxic...
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