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Article

Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs

27 Mar 2020

Abstract excerpt

The molecular mechanisms governing the secretion of the non-coding genome are poorly understood. We show herein that cyclin D1, the regulatory subunit of the cyclin-dependent kinase that drives cell-cycle progression, governs the secretion and relative proportion of secreted non-coding RNA subtypes (miRNA, rRNA, tRNA, CDBox, scRNA, HAcaBox. scaRNA, piRNA) in human breast cancer. Cyclin D1 induced the secretion of...

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PMID: 32219337
DOI: 10.1042/cs20191318

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