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Article

Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease.

PloS one - 1 Jan 2020

Buglo Elena, Sarmiento Evan, Martuscelli Nicole Belliard, Sant David W, Danzi Matt C, Abrams Alexander J, Dallman Julia E, Züchner Stephan

Abstract excerpt

A phenomenon of genetic compensation is commonly observed when an organism with a disease-bearing mutation shows incomplete penetrance of the disease phenotype. Such incomplete phenotypic penetrance, or genetic compensation, is more commonly found in stable knockout models, rather than transient knockdown models. As such, these incidents present a challenge for the disease modeling field, although a deeper...

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Identifiers

PMID: 32208444
DOI: 10.1371/journal.pone.0230566
PMCID: PMC7092968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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