Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.

doi:10.1182/blood.2019004492

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.

Blood - 25 Jun 2020

Tausch Eugen, Schneider Christof, Robrecht Sandra, Zhang Can, Dolnik Anna, Bloehdorn Johannes, Bahlo Jasmin, Al-Sawaf Othman, Ritgen Matthias, Fink Anna-Maria, Eichhorst Barbara, Kreuzer Karl-Anton, Tandon Maneesh, Humphrey Kathryn, Jiang Yanwen, Schary William, Bullinger Lars, Mertens Daniel, Lurà Michele Porro, Kneba Michael, Döhner Hartmut, Fischer Kirsten, Hallek Michael, Stilgenbauer Stephan

Abstract excerpt

Genetic parameters are established prognostic factors in chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy, but are less well studied with novel compounds. We assessed immunoglobulin heavy variable chain (IGHV) mutation status, common genomic aberrations, and gene mutations in 421 untreated patients within the CLL14 trial (NCT02242942), comparing obinutuzumab+chlorambucil (GClb) vs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clinical Trials, Phase III as Topic

Share to Genes, Neoplasm

Share to Immunoglobulin Variable Region

Share to Multicenter Studies as Topic

Share to Neoplasm, Residual

Share to Progression-Free Survival

Share to Remission Induction

Source

Open in PubMed

Identifiers

PMID: 32206772
DOI: 10.1182/blood.2019004492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.PMID 32206772Read ↗

Prognostic impact of genetic abnormalities in 536 first-line chronic lymphocytic leukaemia patients without 17p deletion treated with chemoimmunotherapy in two prospective trials: Focus on IGHV-mutated subgroups (a FILO study).Semantic proximity Read ↗

The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatmentSemantic proximity Read ↗

Up to 6.5 years (median 4 years) of follow-up of first-line ibrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and high-risk genomic features: integrated analysis of two phase 3 studies.Semantic proximity Read ↗

Comparison Between Venetoclax-based and Bruton Tyrosine Kinase Inhibitor-based Therapy as Upfront Treatment of Chronic Lymphocytic Leukemia (CLL): A Systematic Review and Network Meta-analysis.Semantic proximity Read ↗

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia.Semantic proximity Read ↗

Integrative prognostic models predict long-term survival after immunochemotherapy in chronic lymphocytic leukemia patients.Semantic proximity Read ↗

Predicting Prognosis in Chronic Lymphocytic Leukemia in the Contemporary Era.Semantic proximity Read ↗

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.Semantic proximity Read ↗

Chronic Lymphocytic Leukemia: 2025 Update on the Epidemiology, Pathogenesis, Diagnosis, and Therapy.Semantic proximity Read ↗

Prognostication in chronic lymphocytic leukemia.Semantic proximity Read ↗

First-Line Treatment of IGHV-Unmutated Chronic Lymphocytic Leukemia: A Network Meta-Analysis of Targeted and Chemoimmunotherapy Regimens.Semantic proximity Read ↗

Lenalidomide treatment and prognostic markers in relapsed or refractory chronic lymphocytic leukemia: data from the prospective, multicenter phase-II CLL-009 trial.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.