Article
Peptide mimotopes alter T cell function in cancer and autoimmunity.
Seminars in immunology - 1 Feb 2020
Slansky Jill E, Nakayama Maki
Abstract excerpt
T cells recognize and respond to self antigens in both cancer and autoimmunity. One strategy to influence this response is to incorporate amino acid substitutions into these T cell-specific epitopes. This strategy is being reconsidered now with the goal of increasing time to regression with checkpoint blockade therapies in cancer and antigen-specific immunotherapies in autoimmunity. We discuss how these amino...
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