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Article

Impact of donor KIRs and recipient KIR/HLA class I combinations on GVHD in patients with acute leukemia after HLA-matched sibling HSCT.

Human immunology - 1 Jun 2020

Mansouri Marzieh, Villard Jean, Ramzi Mani, Alavianmehr Ali, Farjadian Shirin

Abstract excerpt

In addition to T cells, NK cells can also participate in the outcome of hematopoietic stem cell transplantation (HSCT) mainly through the interaction between donor killer cell immunoglobulin-like receptors (KIRs) and recipient human leukocyte antigen (HLA) class I molecules. There is a risk of GVHD other than leukemia relapse after allogeneic HSCT that activation of donor NK cells in the absence of appropriate...

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Identifiers

PMID: 32199702
DOI: 10.1016/j.humimm.2020.03.004

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