Article
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations.
Nature communications - 20 Mar 2020
Trzaska Carole, Amand Séverine, Bailly Christine, Leroy Catherine, Marchand Virginie, Duvernois-Berthet Evelyne, Saliou Jean-Michel, Benhabiles Hana, Werkmeister Elisabeth, Chassat Thierry, Guilbert Romain, Hannebique David, Mouray Anthony, Copin Marie-Christine, Moreau Pierre-Arthur, Adriaenssens Eric, Kulozik Andreas, Westhof Eric, Tulasne David, Motorin Yuri, Rebuffat Sylvie, Lejeune Fabrice
Abstract excerpt
Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. An extract of the mushroom Lepista inversa has recently shown high-efficiency correction of UGA and UAA nonsense mutations. One active constituent of this extract is 2,6-diaminopurine (DAP). In Calu-6 cancer cells, in which TP53...
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