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Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors

19 May 2017

Abstract excerpt

The outer blood-retina barrier is established through the coordinated terminal maturation of the retinal pigment epithelium (RPE), fenestrated choroid endothelial cells (ECs) and Bruch's membrane, a highly organized basement membrane that lies between both cell types. Here we study the contribution of choroid ECs to this process by comparing their gene expression profile before (P5) and after (P30) the critical...

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PMID: 28524846
DOI: 10.1038/ncomms15374

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