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Article

Cxcr4 and Sdf-1 are critically involved in the formation of facial and non-somitic neck muscles.

Scientific reports - 19 Mar 2020

Yahya Imadeldin, Böing Marion, Pu Qin, Puchert Malte, Oedemis Veysel, Engele Jürgen, Brand-Saberi Beate, Morosan-Puopolo Gabriela

Abstract excerpt

The present study shows that the CXCR4/SDF-1 axis regulates the migration of second branchial arch-derived muscles as well as non-somitic neck muscles. Cxcr4 is expressed by skeletal muscle progenitor cells in the second branchial arch (BA2). Muscles derived from the second branchial arch, but not from the first, fail to form in Cxcr4 mutants at embryonic days E13.5 and E14.5. Cxcr4 is also required for the...

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Identifiers

PMID: 32193486
DOI: 10.1038/s41598-020-61960-w
PMCID: PMC7081242

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