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Article

Cell function profiling to assess clone stability.

Biotechnology and bioengineering - 1 Jul 2020

Dobson Paul D, Coss Karen P, Doherty Carolanne, Clifford Jerry, Thompson Ben, James David C

Abstract excerpt

In cell line development the identification of stable Chinese hamster ovary cells for production is a critical but onerous task. The stability trial focus upon high-level attributes can mask profound underlying cellular changes, leading to unstable clones mistakenly being chosen for production. The challenge is to assay underlying cell pathways and subsystems without pushing up cell line development costs....

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Identifiers

PMID: 32181887
DOI: 10.1002/bit.27336
PMCID: PMC7383652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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