Article
Lack of evidence for CDK12 as an ovarian cancer predisposing gene.
Familial cancer - 1 Jul 2020
Eeckhoutte Alexandre, Saint-Ghislain Mathilde, Reverdy Manon, Raynal Virginie, Baulande Sylvain, Bataillon Guillaume, Golmard Lisa, Stoppa-Lyonnet Dominique, Popova Tatiana, Houdayer Claude, Manié Elodie, Stern Marc-Henri
Abstract excerpt
CDK12 variants were investigated as a genetic susceptibility to ovarian cancer in a series of 416 unrelated and consecutive patients with ovarian carcinoma and who carry neither germline BRCA1 nor BRCA2 pathogenic variant. The presence of CDK12 variants was searched in germline DNA by massive parallel sequencing on pooled DNAs. The lack of detection of deleterious variants and the observed proportion of missense...
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