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Article

Association between cystatin C gene polymorphism and the prevalence of white matter lesion in elderly healthy subjects.

Scientific reports - 13 Mar 2020

Maniwa Kyohei, Yano Shozo, Sheikh Abdullah Md, Onoda Keiichi, Mitaki Shingo, Isomura Minoru, Mishima Seiji, Yamaguchi Shuhei, Nabika Toru, Nagai Atsushi

Abstract excerpt

Cystatin C (CST3) is a cysteine protease inhibitor abundant in the central nervous system, and demonstrated to have roles in several pathophysiological processes including vascular remodeling and inflammation. Previously, we showed a relation of CST3 gene polymorphisms with deep and subcortical white matter hyperintensity (DSWMH) in a small case-control study. In this study, we aimed to investigate the relation...

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Identifiers

PMID: 32170118
DOI: 10.1038/s41598-020-61383-7
PMCID: PMC7069982

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