Article
The Natural Large Genomic Deletion Is Unrelated to the Increased Virulence of the Novel Genotype Fowl Adenovirus 4 Recently Emerged in China.
Viruses - 13 Sept 2018
Pan Qing, Wang Jing, Gao Yulong, Cui Hongyu, Liu Changjun, Qi Xiaole, Zhang Yanping, Wang Yongqiang, Wang Xiaomei
Abstract excerpt
Since 2015, severe hydropericardium-hepatitis syndrome (HHS), caused by a highly pathogenic fowl adenovirus 4 (FAdV-4), emerged in China. In our previous study, the FAdV-4 has been identified as a novel genotype with a unique 1966-bp nucleotide deletion (1966Del) between open reading frame 42 and 43. In this study, the natural 1966Del was frequently identified among 17 clinical isolates and other reported Chinese...
Topics
- Adenoviridae
- Adenoviridae Infections
- Animals
- CRISPR-Cas Systems
- Chickens
- China
- Ducks
- Gene Editing
- Genome, Viral
- Genotype
- Phylogeny