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A Kayvirus Distant Homolog of Staphylococcal Virulence Determinants and VISA Biomarker Is a Phage Lytic Enzyme.

Viruses - 7 Mar 2020

Głowacka-Rutkowska Aleksandra, Ulatowska Magdalena, Empel Joanna, Kowalczyk Magdalena, Boreczek Jakub, Łobocka Małgorzata

Abstract excerpt

Staphylococcal bacteriophages of the Kayvirus genus are candidates for therapeutic applications. One of their proteins, Tgl, is slightly similar to two staphylococcal virulence factors, secreted autolysins of lytic transglycosylase motifs IsaA and SceD. We show that Tgl is a lytic enzyme secreted by the bacterial transport system and localizes to cell peripheries like IsaA and SceD. It causes lysis of E. coli...

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Identifiers

PMID: 32156046
DOI: 10.3390/v12030292
PMCID: PMC7150955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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