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Article

CYP3A Polymorphism and Chronic Mercury Intoxication.

Bulletin of experimental biology and medicine - 1 Feb 2020

Chernyak Yu I, Merinova A P

Abstract excerpt

We analyzed the relationship between polymorphic loci of CYP3A genes (CYP3A4 (rs2740574), CYP3A5 (rs776746) and CYP3A7 (rs2257401)) with the development of chronic mercury intoxication. Of 170 men examined, 120 were workers chronically exposed to mercury vapors and 50 were carriers of GG-HSPA1B (+1267A/G) genotype associated with chronic mercury intoxication. Urinary content of 4-hydroxyantipyrine (4-HAP)...

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PMID: 32146629
DOI: 10.1007/s10517-020-04738-4

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