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Article

TATTON: a multi-arm, phase Ib trial of osimertinib combined with selumetinib, savolitinib, or durvalumab in EGFR-mutant lung cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2020

Oxnard G R, Yang J C-H, Yu H, Kim S-W, Saka H, Horn L, Goto K, Ohe Y, Mann H, Thress K S, Frigault M M, Vishwanathan K, Ghiorghiu D, Ramalingam S S, Ahn M-J

Abstract excerpt

BACKGROUND: Osimertinib is a potent, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). The multi-arm phase Ib TATTON study (NCT02143466) was designed to assess the safety and tolerability of osimertinib in combination with other targeted therapies: selumetinib (MEK1/2 inhibitor), savolitinib (MET-TKI), or durvalumab [anti-programmed cell death ligand 1 (anti-PD-L1)...

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PMID: 32139298
DOI: 10.1016/j.annonc.2020.01.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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