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Osimertinib Plus Durvalumab in Patients With EGFR-Mutated, Advanced NSCLC: A Phase 1b, Open-Label, Multicenter Trial.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2022

Ahn Myung-Ju, Cho Byoung Chul, Ou Xiaoling, Walding Andrew, Dymond Angela W, Ren Song, Cantarini Mireille, Jänne Pasi A

Abstract excerpt

INTRODUCTION: EGFR tyrosine kinase inhibitors (TKIs) are recommended for EGFR-mutated NSCLC treatment. EGFR activation up-regulates programmed death-ligand 1 expression and other immunosuppressive factors in NSCLC, causing immune microenvironment remodeling. Osimertinib (an EGFR TKI) plus durvalumab (programmed death-ligand 1 blockade) was evaluated in the TATTON study (NCT02143466). METHODS: This open-label,...

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PMID: 35181499
DOI: 10.1016/j.jtho.2022.01.012

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Osimertinib Plus Durvalumab in Patients With EGFR-Mutated, Advanced NSCLC: A Phase 1b, Open-Label, Multicenter Trial.PMID 35181499Read ↗

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