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Article

Disentangling group specific QTL allele effects from genetic background epistasis using admixed individuals in GWAS: An application to maize flowering.

PLoS genetics - 1 Mar 2020

Rio Simon, Mary-Huard Tristan, Moreau Laurence, Bauland Cyril, Palaffre Carine, Madur Delphine, Combes Valérie, Charcosset Alain

Abstract excerpt

When handling a structured population in association mapping, group-specific allele effects may be observed at quantitative trait loci (QTLs) for several reasons: (i) a different linkage disequilibrium (LD) between SNPs and QTLs across groups, (ii) group-specific genetic mutations in QTL regions, and/or (iii) epistatic interactions between QTLs and other loci that have differentiated allele frequencies between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32130208
DOI: 10.1371/journal.pgen.1008241
PMCID: PMC7075643

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