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Article

Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma.

Nature communications - 28 Feb 2020

Wang Xin, Qin Ge, Liang Xiaoting, Wang Wen, Wang Zhuo, Liao Dan, Zhong Li, Zhang Ruhua, Zeng Yi-Xin, Wu Yuanzhong, Kang Tiebang

Abstract excerpt

Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed in osteosarcoma cell lines and tissues. CBX4 promoted metastasis by transcriptionally up-regulating Runx2 via the recruitment of GCN5 to the Runx2 promoter. The phosphorylation of CBX4 at T437 by casein kinase 1α (CK1α) facilitated its...

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Identifiers

PMID: 32111827
DOI: 10.1038/s41467-020-14870-4
PMCID: PMC7048933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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