Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight

Abstract excerpt

An increasing prevalence of overweight and obesity in people living with HIV has been associated with initiation of antiretroviral therapy with integrase strand transfer inhibitors (INSTIs). An off-target inhibition of the endogenous ligand binding to the human melanocortin 4 receptor (MC4R) has been suggested as a potential mechanism for clinical body weight gain following initiation of dolutegravir, an INSTI....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical Analysis and Sensing Techniques
• Share to Diabetes Treatment and Management
• Share to Regulation of Appetite and Obesity