Genetic Profile and Functional Proteomics of Anal Squamous Cell Carcinoma: Proposal for a Molecular Classification.

doi:10.1074/mcp.RA120.001954

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Genetic Profile and Functional Proteomics of Anal Squamous Cell Carcinoma: Proposal for a Molecular Classification.

Molecular & cellular proteomics : MCP - 1 Apr 2020

Trilla-Fuertes Lucía, Ghanem Ismael, Gámez-Pozo Angelo, Maurel Joan, G-Pastrián Laura, Mendiola Marta, Peña Cristina, López-Vacas Rocío, Prado-Vázquez Guillermo, López-Camacho Elena, Zapater-Moros Andrea, Heredia Victoria, Cuatrecasas Miriam, García-Alfonso Pilar, Capdevila Jaume, Conill Carles, García-Carbonero Rocío, Ramos-Ruiz Ricardo, Fortes Claudia, Llorens Carlos, Nanni Paolo, Fresno Vara Juan Ángel, Feliu Jaime

Abstract excerpt

Anal squamous cell carcinoma is a rare tumor. Chemo-radiotherapy yields a 50% 3-year relapse-free survival rate in advanced anal cancer, so improved predictive markers and therapeutic options are needed. High-throughput proteomics and whole-exome sequencing were performed in 46 paraffin samples from anal squamous cell carcinoma patients. Hierarchical clustering was used to establish groups de novo Then,...

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PMID: 32107283
DOI: 10.1074/mcp.RA120.001954
PMCID: PMC7124473

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