Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens

27 Feb 2020

Abstract excerpt

The development of chemotherapies against eukaryotic pathogens is especially challenging because of both the evolutionary conservation of drug targets between host and parasite, and the evolution of strain-dependent drug resistance. There is a strong need for new nontoxic drugs with broad-spectrum activity against trypanosome parasites such as Leishmania and Trypanosoma. A relatively untested approach is to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA modifications and cancer
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32106219
DOI: 10.1371/journal.pntd.0007983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogensPMID 32106219Read ↗

Targeting tRNA-Synthetase Interactions towards Novel Therapeutic Discovery Against Eukaryotic PathogensSemantic proximity Read ↗

Structural analyses of the malaria parasite aminoacyl‐tRNA synthetases provide new avenues for antimalarial drug discoverySemantic proximity Read ↗

Discovery of tREP-18, a novel class of <i>t</i> RNA encoded peptide with potent leishmanicidal activitySemantic proximity Read ↗

Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.Semantic proximity Read ↗

Aminoacyl tRNA Synthetases as Malarial Drug Targets: A Comparative Bioinformatics StudySemantic proximity Read ↗

Multidimensional Phylogenetic Metrics Identify Class I Aminoacyl-tRNA Synthetase Evolutionary Mosaicity and Inter-Modular Coupling.Semantic proximity Read ↗

In silico prediction of antimalarial drug target candidatesSemantic proximity Read ↗

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetaseSemantic proximity Read ↗

Targeting with Structural Analogs of Natural Products the Purine Salvage Pathway in Leishmania (Leishmania) infantum by Computer-Aided Drug-Design ApproachesSemantic proximity Read ↗

Allelic Variation at tRNA Genes in Three Nematode Species Indicates Mutation Load Despite Strong Purifying Selection.Semantic proximity Read ↗

Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids.Semantic proximity Read ↗

Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African TrypanosomiasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.