Tridiscorhabdin and Didiscorhabdin, the First Discorhabdin Oligomers Linked with a Direct C–N Bridge from the Sponge Latrunculia biformis Collected from the Deep Sea in Antarctica

Abstract excerpt

Guided by LC-MS/MS molecular networking-based metabolomics and cytotoxic activity, two new discorhabdin-type alkaloids, tridiscorhabdin ( 1 ) and didiscorhabdin ( 2 ), were isolated from the sponge Latrunculia biformis, collected from the Weddell Sea (Antarctica) at −291 m depth. Their structures were established by HRESIMS, NMR, [α] D, and ECD data coupled with DFT calculations. Both compounds bear a novel C–N...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Marine Sponges and Natural Products
• Share to Microbial Natural Products and Biosynthesis