Article
Nodulisporic acid B, B1, and B2: a series of 1'-deoxy-nodulisporic acids from Nodulisporium sp.
Bioorganic & medicinal chemistry letters - 21 Oct 2002
Ondeyka John G, Dahl-Roshak Arlene M, Tkacz Jan S, Zink Deborah L, Zakson-Aiken Michelle, Shoop Wesley L, Goetz Michael A, Singh Sheo B
Abstract excerpt
During the re-isolation of the lead compound nodulisporic acid A (1a) and targeted chemical screening for related compounds, we discovered a series of 1'-deoxy congeners named herein nodulisporic acids B (1b), B1 (2b), and B2 (3b). In comparison with nodulisporic acid A, these compounds were less active and were chemically unstable resulting into formation of delta23 dehydro derivatives. Therefore, these...
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