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Article

Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and leptin response.

Biology of reproduction - 26 May 2020

Guerra Damian D, Bok Rachael, Cari Evelyn Llerena, Nicholas Cari, Orlicky David J, Johnson Joshua, Hurt K Joseph

Abstract excerpt

Hypothalamic neuronal nitric oxide synthase (nNOS) potentiates adult female fertility in rodents by stimulating gonadotropin releasing hormone (GnRH) secretion, which in turn promotes luteinizing hormone (LH) release and ovulation. The mechanism of hypothalamic nNOS activation is not clear but could be via nNOS serine1412 (S1412) phosphorylation, which increases nNOS activity and physiologic NO effects in other...

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Share to Gene Expression Regulation, Enzymologic
Share to Hypothalamo-Hypophyseal System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leptin

Share to Mice, Inbred C57BL

Share to Nitric Oxide Synthase Type I

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Source

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Identifiers

PMID: 32101284
DOI: 10.1093/biolre/ioaa025
PMCID: PMC8515839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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