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Article

Expanding the Scope of Immunotherapy in Colorectal Cancer: Current Clinical Approaches and Future Directions.

BioMed research international - 1 Jan 2020

Kreidieh Malek, Mukherji Deborah, Temraz Sally, Shamseddine Ali

Abstract excerpt

The success of immune checkpoint inhibitors (ICIs) in an increasing range of heavily mutated tumor types such as melanoma has culminated in their exploration in different subsets of patients with metastatic colorectal cancer (mCRC). As a result of their dramatic and durable response rates in patients with chemorefractory, mismatch repair-deficient-microsatellite instability-high (dMMR-MSI-H) mCRC, ICIs have...

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Identifiers

PMID: 32090113
DOI: 10.1155/2020/9037217
PMCID: PMC7008242

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