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Article

Phenotypic Characterization and Comparison of Cystic Fibrosis Rat Models Generated Using CRISPR/Cas9 Gene Editing.

The American journal of pathology - 1 May 2020

McCarron Alexandra, Cmielewski Patricia, Reyne Nicole, McIntyre Chantelle, Finnie John, Craig Fiona, Rout-Pitt Nathan, Delhove Juliette, Schjenken John E, Chan Hon Y, Boog Bernadette, Knight Emma, Gilmore Rodney C, O'Neal Wanda K, Boucher Richard C, Parsons David, Donnelley Martin

Abstract excerpt

Animal models of cystic fibrosis (CF) are essential for investigating disease mechanisms and trialing potential therapeutics. This study generated two CF rat models using clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeats-associated protein 9 gene editing. One rat model carries the common human Phe508del (ΔF508) CF transmembrane conductance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32084371
DOI: 10.1016/j.ajpath.2020.01.009

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