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Article

New insights into the pathomechanism of cyclic neutropenia.

Annals of the New York Academy of Sciences - 1 Apr 2020

Mir Perihan, Klimiankou Maksim, Findik Betuel, Hähnel Karin, Mellor-Heineke Sabine, Zeidler Cornelia, Skokowa Julia, Welte Karl

Abstract excerpt

Cyclic neutropenia (CyN) is a hematologic disorder in which peripheral blood absolute neutrophil counts (ANCs) show cycles of approximately 21-day intervals. The majority of CyN patients harbor ELANE mutations, but the mechanism of ANC cycling is unclear. We performed analysis of bone marrow (BM) subpopulations in CyN patients at the peak and the nadir of the ANC cycle and detected high proportions of BM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32083314
DOI: 10.1111/nyas.14309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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