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Article

ErbB4 Mutation that Decreased NRG1-ErbB4 Signaling Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Sun Lin, Cheng Baoying, Zhou Yuxun, Fan Yating, Li Wei, Qiu Qi, Fang Yuan, Xiao Shifu, Zheng Honghua, Li Xia

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) includes a large spectrum of neurodegenerative disorders. OBJECTIVE: To identify the relationship of ErbB4 mutation and ALS/FTD. METHODS: Here, we report an atypical case of frontal variant behavioral abnormalities at the initial stage, a stable plateau stage of 5 years, and paralysis involving both upper and lower motor neurons followed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32065797
DOI: 10.3233/JAD-191230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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