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Article

Insights into the Functions of eIF4E-Biding Motif of VPg in Potato Virus A Infection.

Viruses - 11 Feb 2020

Saha Shreya, Mäkinen Kristiina

Abstract excerpt

The interaction between the viral protein genome-linked (VPg) and eukaryotic initiation factor 4E (eIF4E) or eIF(iso)4E of the host plays a crucial role in potyvirus infection. The VPg of potato virus A (PVA) contains the Tyr-X-X-X-X-Leu-phi (YXXXLΦ) binding motif for eIF(iso)4E. In order to investigate its role in PVA infection, we substituted the conserved tyrosine and leucine residues of the motif with alanine...

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Identifiers

PMID: 32053987
DOI: 10.3390/v12020197
PMCID: PMC7077193

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