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Scanning electron microscopy and machine learning reveal heterogeneity in capsular morphotypes of the human pathogen Cryptococcus spp.

Scientific reports - 11 Feb 2020

Lopes William, Cruz Giuliano N F, Rodrigues Marcio L, Vainstein Mendeli H, Kmetzsch Livia, Staats Charley C, Vainstein Marilene H, Schrank Augusto

Abstract excerpt

Phenotypic heterogeneity is an important trait for the development and survival of many microorganisms including the yeast Cryptococcus spp., a deadly pathogen spread worldwide. Here, we have applied scanning electron microscopy (SEM) to define four Cryptococcus spp. capsule morphotypes, namely Regular, Spiky, Bald, and Phantom. These morphotypes were persistently observed in varying proportions among yeast...

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PMID: 32047210
DOI: 10.1038/s41598-020-59276-w
PMCID: PMC7012869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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