Article
Genotypic characterization of 'inferred' rifampin mutations in GenoType MTBDRplus assay and its association with phenotypic susceptibility testing of Mycobacterium tuberculosis.
Diagnostic microbiology and infectious disease - 1 Apr 2020
Singhal Ritu, Anthwal Divya, Kumar Gavish, Sah Grish, Salfinger Max, Choudhury Sangeeta, Arora Jyoti, Bhalla Manpreet, Myneedu Vithal P, Sarin Rohit, Haldar Sagarika
Abstract excerpt
In GenoType MTBDRplus assay [line probe assay (LPA)], when Mycobacterium tuberculosis (M. tuberculosis) sample DNA fails to hybridize to at least 1 rpoB wild-type probe and any mutation probe, it is inferred as rifampin (RIF)-resistant. In this study, we sought to identify such 'inferred' mutations in M. tuberculosis isolates (n = 203) by rpoB gene sequencing and determined their association with phenotypic...
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