Article
MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis.
Journal of clinical microbiology - 1 Apr 2016
Seifert Marva, Georghiou Sophia B, Catanzaro Donald, Rodrigues Camilla, Crudu Valeriu, Victor Thomas C, Garfein Richard S, Catanzaro Antonino, Rodwell Timothy C
Abstract excerpt
Accurate identification of drug-resistantMycobacterium tuberculosisis imperative for effective treatment and subsequent reduction in disease transmission. Line probe assays rapidly detect mutations associated with resistance and wild-type sequences associated with susceptibility. Examination of molecular-level performance is necessary for improved assay result interpretation and for continued diagnostic...
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