Article
Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila.
Nucleic acids research - 17 Apr 2020
Nitschko Volker, Kunzelmann Stefan, Fröhlich Thomas, Arnold Georg J, Förstemann Klaus
Abstract excerpt
RNA interference targets aberrant transcripts with cognate small interfering RNAs, which derive from double-stranded RNA precursors. Several functional screens have identified Drosophila blanks/lump (CG10630) as a facilitator of RNAi, yet its molecular function has remained unknown. The protein carries two dsRNA binding domains (dsRBD) and blanks mutant males have a spermatogenesis defect. We demonstrate that...
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