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Article

Irisin induces trophoblast differentiation via AMPK activation in the human placenta

5 Feb 2020

Abstract excerpt

Irisin, an adipokine, regulates differentiation and phenotype in various cell types including myocytes, adipocytes, and osteoblasts. Circulating irisin concentration increases throughout human pregnancy. In pregnancy disorders such as preeclampsia and gestational diabetes mellitus, circulating irisin levels are reduced compared to healthy controls. To date, there are no data on the role and molecular function of...

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PMID: 32020629
DOI: 10.1002/jcp.29613

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