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Article

Genetic Variation and Potential for Resistance Development to the tTA Overexpression Lethal System in Insects.

G3 (Bethesda, Md.) - 9 Apr 2020

Knudsen Katherine E, Reid William R, Barbour Traci M, Bowes Laci M, Duncan Juliana, Philpott Elaina, Potter Samantha, Scott Maxwell J

Abstract excerpt

Release of insect pests carrying the dominant lethal tetracycline transactivator (tTA) overexpression system has been proposed as a means for population suppression. High levels of the tTA transcription factor are thought to be toxic due to either transcriptional squelching or interference with protein ubiquitination. Here we utilized the Drosophila melanogaster Genetic Reference Panel (DGRP) to examine the...

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Identifiers

PMID: 32019873
DOI: 10.1534/g3.120.400990
PMCID: PMC7144068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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