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Article

Genetic diversity of Plasmodium vivax and Plasmodium falciparum lactate dehydrogenases in Myanmar isolates.

Malaria journal - 4 Feb 2020

Lee Jinyoung, Kim Tae Im, Lê Hương Giang, Yoo Won Gi, Kang Jung-Mi, Ahn Seong-Kyu, Myint Moe Kyaw, Lin Khin, Kim Tong-Soo, Na Byoung-Kuk

Abstract excerpt

BACKGROUND: Plasmodium lactate dehydrogenase (pLDH) is a major target in diagnosing the erythrocytic stage of malaria parasites because it is highly expressed during blood-stage parasites and is distinguished from human LDH. Rapid diagnostic tests (RDTs) for malaria use pLDH as a target antigen; however, genetic variations in pLDH within the natural population threaten the efficacy of pLDH-based RDTs. METHODS:...

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Identifiers

PMID: 32019541
DOI: 10.1186/s12936-020-3134-y
PMCID: PMC7001217

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Source receipt: pubmed, retrieved 7 Sept 2026.

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