Article
Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparum.
Malaria journal - 9 Jan 2018
Simpalipan Phumin, Pattaradilokrat Sittiporn, Harnyuttanakorn Pongchai
Abstract excerpt
BACKGROUND: Antigen-detecting rapid diagnostic tests (RDTs) have been recommended by the World Health Organization for use in remote areas to improve malaria case management. Lactate dehydrogenase (LDH) of Plasmodium falciparum is one of the main parasite antigens employed by various commercial RDTs. It has been hypothesized that the poor detection of LDH-based RDTs is attributed in part to the sequence diversity...
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