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Nisin Z and Lacticin 3147 Improve Efficacy of Antibiotics Against Clinically Significant Bacteria

1 Dec 2019

Abstract excerpt

Aim: To determine if bacteriocins improve antibiotic efficacy. Materials & methods: Deferred antagonism assays identified bacteriocins with activity. Growth curves and time kill assays demonstrated bactericidal activity of antimicrobial combinations, and checkerboard assays confirmed synergy. Methicillin-resistant Staphylococcus aureus-infected porcine skin model determined ex vivo efficacy. Results:...

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PMID: 32019322
DOI: 10.2217/fmb-2019-0153

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