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Article

Bacteriophage-Antibiotic Combination Strategy: an Alternative against Methicillin-Resistant Phenotypes of Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 23 Jun 2020

Kebriaei Razieh, Lev Katherine, Morrisette Taylor, Stamper Kyle C, Abdul-Mutakabbir Jacinda C, Lehman Susan M, Morales Sandra, Rybak Michael J

Abstract excerpt

Comparative time-kill experiments with Staphylococcus aureus bacteriophage (phage) Sb-1 alone and phage-antibiotic combinations (PACs) against two methicillin-resistant S. aureus (MRSA) strains have shown synergy with both daptomycin-phage and vancomycin-phage combinations. PACs prevented development of phage resistance and demonstrated bactericidal activity for all triple combinations. In addition, the...

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Identifiers

PMID: 32393490
DOI: 10.1128/AAC.00461-20
PMCID: PMC7318012

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