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Article

Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3.

Aging - 29 Jan 2020

Ji Dong, Chen Guo-Feng, Wang Jin-Cheng, Ji Si-Han, Wu Xue-Wen, Lu Xiao-Jie, Chen Jin-Lian, Li Jing-Tao

Abstract excerpt

Previous circular RNA (circRNA) microarray analyses have uncovered an abnormal expression of hsa_circ_0070963 in hepatic stellate cells (HSCs). However, the specific role of hsa_circ_0070963 in liver fibrosis remains unknown. Here, we show that hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. Moreover, we demonstrated that hsa_circ_0070963 levels were reduced during liver fibrosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32003753
DOI: 10.18632/aging.102705
PMCID: PMC7053641

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